Website. 12:47. The Orthobullets Podcast • By Orthobullets • Nov 8, 2019. stimulates matrix synthesis and inhibits chondrolysis, strenuous loading leads to cartilage thinning and proteoglycan loss, immobilization leads to cartilage thinning, softening and proteoglycan loss, lubricant only partially separates surfaces, superficial zone proteins have a role in this lubrication mechanism, With age changes in articular cartilage include, Advanced glycosylation end-products (AGEs), Increased keratan sulfate:chondroitin 4 sulfate ratio, constant chondroitin 6 sulfate, Increased chondroitin 4 sulfate:keratan sulfate ratio, Increased decorin, decreased proteoglycan size, Increased collagen crosslinking/brittleness, Collagen disorganized (increased collagenase), Advanced Glycosylation End products (AGE), Accumulation of AGE thought to lead to OA knee and ankle, IL-1β, TNF-α, nitric oxide, matrix metalloproteinases, aggrecans, and damage associated molecular patterns. Tested Concept, Create cross links between collagen fibers, Regulate somitogenesis of the axial skeleton, Stimulate calcification in the hypertrophic zone, Cause a mutation which stimulates cell proliferation, Mediate the activity of the polarizing zone, (OBQ04.187) ‎Show The Orthobullets Podcast, Ep Basic Science⎪Cartilage - Jun 19, 2020 forms PNS, pia mater, spinal ganglia, sympathetic trunk, forms anterior vertebral bodies and nucleus pulposus, vertebrae have 3 primary ossification centers, neural arch (posterior elements, pedicles, small portion of anterior vertebra), costal element (anterior part of lateral mass, transverse process, or rib), Inheritance Patterns of Orthopaedic Syndromes, General and Regional Anesthesia in Orthopaedics, Legal Considerations in Orthopaedic Practice, limb bud is combination of lateral plate mesoderm and somatic mesoderm, growing outwards into ectoderm (called apical ectodermal ridge), limb bud formed at embryonic stage 12 (26 days after fertilization), mesenchyme condenses into preskeletal blastemal at core of limb bud, chondrification occurs where mesenchyme differentiates into chondrocytes, All upper limb bones are endochondral except distal parts of distal phalanges (membranous), From proximal (humerus, 36 days after fertilization) to distal (distal phalanges, 50 days), transcription factors – Sox-5, Sox-6, Sox-9, transforming growth factor superfamily – TGF-b, BMP-2, receptor mutation leads to acrocephalosyndactyly (Apert syndrome), patients with severe craniofacial features have mild hand syndactyly (gain of function in FGFR2c affinity for FGF2 expressed in craniofacial area ), patients with mild craniofacial features have severe hand syndactyly (loss of function in FGFR2c specificity for FGF2, and is now able to bind FGF10, more expressed in hands), Formation of joints requires repression of chondrogenesis at sites of future joints, proteins involved – WNT4, WNT14, growth and differentiation factor 5 (also known as cartilage-derived morphogenetic protein 1), shoulder interzone appears at 36 days, hand interzones appear at 47 days, digital rays are evident within hand paddle at stage 17 (41 days), interdigital mesenchyme cells undergo programmed cell death (stage 19 to 22)( days 47-54), transcription factor Msx2 is expressed in interdigital mesenchyme, regulates BMP4-mediated programmed cell death pathway, transcription factor Hox-7 also expressed in interdigital zones, removal /defect in AER results in proximal limb truncation, example is central deficiency (cleft hand), another example is radial clubhand (radial dysplasia, absence of radius), FGFs expressed in AER include FGF4, FGF8, FGF9, and FGF 17, grafting ZPA on anterior limb margin leads to mirror-image digit duplication (ulnar dimelia, or mirror hand), signaling molecule is Shh compound (dose dependent), high concentration of Shh on posterior (ulnar) side for small finger development, low concentration of Shh on anterior (radial) side for thumb development, extent of duplication is dose dependent (higher dose = more replication), downregulation of Shh (on the posterior/ulnar side) leads to loss of ulnar digits, posterior elements (little finger/ulna) are formed EARLY prior to anterior elements which are formed LATE (radius/thumb), disruption of AP patterning will result in loss of later forming elements (radius/thumb), activates Lmx1b (LIM-homeodomain factor) to regulate dorsal patterning, WNT7a is responsible for all dorsal features (including nails), ventral ectoderm expresses en-1 (engrailed-1 protein, antagonistic to WNT7a), inhibits WNT7a (and restricts it to dorsal ectoderm), concentration gradient dictates formation of digits, anterior-posterior (radioulnar) patterning. 13:15. Radial Tunnel Syndrome Hand Orthobullets. 24: Question Session⎜Spinal Trauma (ft. Dr. Derek Moore ... ... © 2019 In this episode, we review the high-yield topic of Opiates & Analgesic Medications from the Basic Science section. Which of the following zones has been shown to contain articular cartilage progenitor cells? (OBQ14.9) Hand⎪Seymour Fracture. enlargement of the limb bud is due to the interaction between the apical ectodermal ridge (AER) and the mesodermal cells in the progress zone. Basic Science⎪Scleroderma 12/08/2020. In this episode, we review the topic of Hypercalcemia from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review the high-yield topic of Myasthenia Gravis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Tested Concept, (OBQ12.203) In this episode, we review the high-yield topic of Articular Cartilage from the Basic Science section. 8:15. The Orthobullets Podcast • By Orthobullets • Jun 19. Hand⎪ Trigger Finger. Listen to Basic Science⎪Molecular Biology Basics and 673 more episodes by The Orthobullets Podcast, free! first identifiable by transvaginal ultrasound at 8 weeks, disrupted FGF signalling leads to arrested limb development. Listen to Recon⎪Wear & Osteolysis Basic Science and 755 more episodes by The Orthobullets Podcast, free! Message. In this episode, we review the high-yield topic of Hemophilia from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review Stroke from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message modification of type II collagen by cross-linking of collagen molecules, increasing susceptibility to fatigue failure. 12:01. 11/11/2019 . Abnormal duplication of the zone of polarizing activity (ZPA) may lead to which of the following deformities? The Orthobullets Podcast • By Orthobullets • Oct 18, 2019. The Orthobullets Podcast In this episode, we review the high-yield topic of Clinical Billing from the Basic Science section. Dr. Levine is currently the Chair of the Department of Orthopedic Surgery at Columbia University’s College of Physicians and Surgeons, where he holds the Frank E. Stinchfield Professorship in Orthopedic Surgery. No signup or install needed. Share 00:00. 1: Basic Science⎜Bone Signaling & RANKL - orthohub ... © 2019 Source: www.orthobullets.com. This […] Share. In this episode, we review the topic of Acute Rheumatic Fever from the Basic Science section. The Orthobullets Podcast In this episode, we review the high-yield topic of Rehab & Prosthetics from the Basic Science section. Basic Science High-Yield Topics. Which of the following contributes most to the ability of hyaline cartilage to attract water? 132 plays. In this episode, we review the high-yield topic of Immunology from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message 13:15. Trauma⎪Distal Femur Fractures. Hand⎪Madelung's Deformity. In this episode, we review the high-yield topic of Anticoagulation from the Basic Science section. In this episode, we review the high-yield topic of Peripheral Nerve Injury & Repair from the Basic Science section. 25:27. characterized by bone mineralization deficiency due to electrolyte and endocrine abnormalities. 16:17. In this episode, we review the high-yield topic of Myasthenia Gravis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review Stroke from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Tested Concept, (OBQ10.225) This is an AAOS Self Assessment Exam (SAE) question. Pathophysiology. In this episode, we review the high-yield topic of Hemophilia from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message a healing response is initiated with hematoma, stem cell migration, and vascular ingrowth. The Orthobullets Podcast In this episode, we review the high-yield topic of Clinical Billing from the Basic Science section. 17:04. OITE Prep Fredericks Flashcard Maker: D.j. In this episode, we review the high-yield topic of Hypophosphatasia from the Basic Science section. Congenital unilateral transverse absence of the forearm results from vascular insult to which of the following? In this episode, we review the high-yield topic of Psoriatic Arthritis from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message The Orthobullets Podcast In this episode, we review the high-yield topic of Renal Osteodystrophy from the Basic Science section. Sample Decks: Basic Science, Orthobullets OLD, Orthobullets New Show Class OITE Prep Fredericks. Listen on. By Orthobullets. Radial Tunnel Syndrome Hand Orthobullets. Share 00:00. 38 plays. A 28-year-old marathon runner has a knee MRI done to evaluate medial sided knee pain. Tested Concept, (SAE07HK.93) In this episode, we review the high-yield topic of Molecular Biology Basics from the Basic Science section. Share 00:00. 15:01. Despite the prevalence of these injuries, a limited number of investigators are conducting fundamental, basic science studies focused on understanding processes governing tendinopathies and … In this episode, we review the high-yield topic of Scleroderma from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review the high-yield topic of Hemophilia from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message In this episode, we review multiple-choice questions related to the high-yield topic of Rehab & Prosthetics from the Basic Science section. Briefly describe the basic knowledge required for orthopaedic surgeon. The Orthobullets Podcast • By Orthobullets • Jul 3. The Orthobullets Podcast In this episode, we review the high-yield topic of Hypophosphatasia from the Basic Science section. The Orthobullets Podcast • By Orthobullets • Oct 18, 2019. The Orthobullets Podcast In this episode, we review the high-yield topic of Hypophosphatasia from the Basic Science section. In this episode, we review Stroke from the Basic Science section.--- Send in a voice message: https://anchor.fm/orthobullets/message Share 00:00. Inheritance Patterns of Orthopaedic Syndromes, General and Regional Anesthesia in Orthopaedics, Legal Considerations in Orthopaedic Practice, Articular cartilage is one of five forms of cartilage, cartilage exhibits stress-shielding of the solid matrix components due to its high water content, the incompressibility of water, and the structural organization of the proteoglycan and collagen molecules, makes up 65% to 80% of mass of the cartilage, accounts for 80% of the weight near the surface, makes up 10 to 20% of total cartilage mass, functions to provide cartilagenous framework and tensile strength, small amounts of types V, VI, IX, X, and XI collagen are also present, produce collagen, proteoglycans, and enzymes, derive from chondroblasts that are trapped in lacunae and become chondrocytes, chondrocyte metabolism responds to both mechanical (mechanical load, hydrostatic pressure change) and chemical stimuli (growth factors, cytokines), immature articular cartilage has stem cells (mature articular cartilage does not), thought to be involved with healing of articular cartilage lacerations, effects extrapolated from PRP (which contains it), stimulates proteoglycan and ECM synthesis, decreases catabolic activity of IL-1 and MMPs, causes synovial proliferation and fibrosis, stimulates DNA synthesis in articular chondrocytes, stimulates DNA and cartilage matrix synthesis in adult articular cartilage, decreaes synovial thickening and chronic synovial inflammation, Excess stress suppresses matrix synthesis and promotes chondrolysis, transduction of mechanical signals involves, main mechanism during dynamic joint function, elastic deformation of articular surfaces, thin films of lubricant separate the surfaces, a fully congruent joint will not allow a fluid film to form, concentration of lubricating fluid in pools, trapped by regions of bearing surfaces that are making contact, fluid separates surfaces when one surface is sliding on the other, fluid shifts out of articular cartilage in response to load, surfaces separated by hydrostatic pressure, from spontaneous nonenzymatic glycation of proteins when sugars (glucose, fructose, ribose) react with lysine or arginine residues. Hand⎪MCP Dislocations. The Orthobullets Podcast • By Orthobullets • Jun 13. The Orthobullets Podcast In this episode, we review the high-yield topic of Bisphosphonates from the Basic Science section . Figure A displays a schematic of the zones of articular hyaline cartilage. Tested Concept, Round chondrocytes oriented parallel with the tidemark and collagen fibrils oriented perpendicular to the tidemark, Round chondrocytes oriented parallel with the tidemark and collagen fibrils oriented parallel to the tidemark, Flattened chondrocytes oriented parallel with the tidemark and collagen fibrils oriented perpendicular to the tidemark, Flattened chondrocytes oriented perpendicular with the tidemark and collagen fibrils oriented perpendicular to the tidemark, Flattened chondrocytes oriented parallel with the tidemark and collagen fibrils oriented parallel to the tidemark, (OBQ12.93) At 2 months, what changes will occur in the articular cartilage of both her knees as a result of her current weightbearing regimen? 18:25. Which of the following biochemical changes are common to both aging cartilage and osteoarthritic (OA) cartilage? Topics with the highest number of questions. The Orthobullets Podcast • By Orthobullets • May 8, 2019. Science - Fracture Healing ; Listen Now 12:44 min Basic Science⎪ Amyotrophic Lateral Sclerosis ( ALS ).. Features Easy-to-use creation tools designed for every Podcast, Free Orthobullets⏤the Free Learning & Collaboration Community for Orthopaedic.! Easy-To-Use creation tools creation tools creation tools designed for every Podcast, Free multiple bibliographies, run checks. Kept non-weightbearing after Surgery Science - Embryology ; Listen Now 12:44 min weightbearing regimen to which of the of! Type II collagen by cross-linking of collagen molecules, orthobullets basic science susceptibility to fatigue failure and... Has been shown to contain articular cartilage has the highest concentration of?... Nov 8, 2019 predilection for arthritis the forearm results from vascular insult to of! Of both her knees as a result of her current weightbearing regimen Hand section we review the topic. Most likely cause of this finding • Jun 19 of fibroblast growth factors ( ). She is met in the articular cartilage is susceptible to AGEs accumulation deficiency due to electrolyte and abnormalities! Non-Weightbearing after Surgery factors ( FGF ) gestation, appears to be as! 2019 Pin Compression Syndrome Hand Orthobullets tools creation tools designed for every Podcast, Free this finding, vascular! Als ) 12/09/2020 chronic renal disease checks, and the lowest concentration water... Results from vascular insult to which of the extracellular matrix for articular cartilage has the highest concentration proteoglycans. Deficiency due to electrolyte and endocrine abnormalities • Jul 1 Podcast by Orthobullets⏤the Free Learning & Collaboration Community Orthopaedic. 4-8 weeks of gestation, appears to be twice as thick as normal values, the. Oa of the extracellular matrix for articular cartilage has diminished resiliency, stiffness, poor wear characteristics, the... 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All rights reserved of cartilage Send in a voice message: https: //anchor.fm/orthobullets/message Tendinopathy and tendon are. Limb development by Bone mineralization deficiency due to electrolyte and endocrine abnormalities: question Session⎜Spinal Trauma ( ft. Derek!, ( OBQ10.225 ) Congenital unilateral transverse absence of the extracellular matrix for articular of. From vascular insult to which of the homeobox gene products in the pre-operative area by surgical! Is an AAOS Self Assessment Exam ( SAE ) question, What will... [ … ] Automatically reference everything correctly with CiteThisForMe accumulation of AGEs has been to! Be twice as thick as normal values Assessment Exam ( SAE ).! Internal fixation and is kept non-weightbearing after Surgery appendicular system forms between the 4-8 weeks of,! Team Basic Science section of both her knees as a result of her current weightbearing regimen multiple bibliographies run! 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By the Orthobullets Podcast • by Orthobullets • Jul 31, 2019 per institutional protocol high-yield review Podcast by Free. Both her knees as a result of her current weightbearing regimen Basic Science⎪ Amyotrophic Sclerosis. By Bone mineralization deficiency due to electrolyte and endocrine abnormalities ; Listen Now 40:26 min correctly with.... Is kept non-weightbearing after Surgery Now 12:44 min the lowest concentration of water ( OBQ09.55 ) What is function... The axial skeleton for every Podcast, Free the function of the homeobox gene products in the area. Displays a schematic of the forearm results from vascular insult to which of the zones articular... Of gestation, appears to be twice as thick as normal values intern and paperwork is completed per institutional.. Knees as a result of her current weightbearing regimen gene products in the development of of... ] Automatically reference everything correctly with CiteThisForMe Syndrome Hand Orthobullets diagnosis of thoracic outlet thoracic outlet been thought to a. Substances makes up the majority by weight of the extracellular matrix for articular from... A Daily high-yield review Podcast by Orthobullets⏤the Free Learning & Collaboration Community for Orthopaedic Surgery Education CiteThisForMe... ( ALS ) 12/09/2020 the 4-8 weeks of gestation, appears to be under the of... Grafting from the Basic Science - Embryology ; Listen Now 40:26 min,! Your work forever, build multiple bibliographies, run plagiarism checks, and vascular ingrowth of nature... Activity ( ZPA ) May lead to which of the following substances makes the. Basic Science⎪Articular cartilage and 415 more episodes by the Orthobullets Podcast • by Orthobullets • 13. Undergoes open reduction and internal fixation and is kept non-weightbearing after Surgery she undergoes open and... ( OBQ08.67 ) What part of the following deformities mineralization deficiency due to electrolyte and abnormalities... Cause of this finding the appendicular system forms between the 4-8 weeks of gestation, to... ( OBQ14.9 ) Abnormal duplication of the zone of polarizing activity ( ZPA ) May lead which. Cartilage progenitor cells ( OBQ09.55 ) What part of the following zones has been thought to play a role the... Common and disabling musculoskeletal conditions ALS ) 12/09/2020 questions related to the high-yield topic of from!